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Expert Option 审查和测试

Expert Opinion on Pharmacotherapy, Volume 23, Issue 11 (2022)

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An overview of ozanimod as a therapeutic option for adults with moderate-to-severe active ulcerative colitis

Introduction: Ulcerative colitis (UC) is a chronic inflammatory condition of the gastrointestinal tract involving a dysregulated immune response. Sphingosine-1-phosphate (S1P) is involved in immune cell regulation. S1P-receptor modulators, such as ozanimod, inhibit lymphocyte migration and have therapeutic potential in UC.

Areas covered: Ozanimod is the first S1P-receptor modulator approved for the treatment of UC. It acts as a functional antagonist, causing internalization of S1P receptors on T-cells. Lymphocyte egress from lymph nodes is inhibited, and Expert Option 审查和测试 migration to sites of active inflammation is curtailed. There are several S1P-receptor subtypes, present in various organs, which inform understanding of ozanimod's side-effect profile including bradycardia and macular Expert Option 审查和测试 edema. In this review, the authors discuss the mechanism of action, pharmacokinetics, clinical efficacy, and safety profile of ozanimod in the treatment of patients with moderate-to-severe UC.

Expert Expert Option 审查和测试 opinion: The S1P-receptor modulator ozanimod is an oral small molecule with a rapid Expert Option 审查和测试 onset of action and a novel therapeutic mechanism in the treatment of UC. It Expert Option 审查和测试 is an effective treatment both in bio-naïve and bio-exposed patients. Although the safety profile of ozanimod looks favorable, more long-term data are needed. Further studies are required to compare Expert Option 审查和测试 ozanimod to currently available therapies to best define its positioning in UC treatment algorithms.

Keywords: Inflammatory bowel disease; ozanimod; small molecules; sphingosine-1-phosphate receptor modulators; ulcerative colitis.

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Choi D, Stewart AP, Bhat S. Choi D, et al. Ann Pharmacother. 2022 May;56(5):592-599. doi: 10.1177/10600280211041907. Epub 2021 Aug 22. Ann Pharmacother. 2022. PMID: 34423657 Expert Option 审查和测试 Review.

Aoun R, Hanauer S. Aoun R, et al. Expert Rev Gastroenterol Hepatol. 2022 May;16(5):411-423. doi: 10.1080/17474124.2022.2065258. Expert Rev Gastroenterol Hepatol. 2022. PMID: Expert Option 审查和测试 35400292 Review.

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Argollo M, Furfaro F, Gilardi D, Roda G, Allocca M, Peyrin-Biroulet L, Danese S. Argollo M, et al. Expert Opin Biol Ther. 2020 Apr;20(4):413-420. doi: 10.1080/14712598.2020.1732919. Epub 2020 Feb 25. Expert Opin Biol Ther. 2020. PMID: 32093531 Review.

Sandborn WJ, Feagan Expert Option 审查和测试 BG, Wolf DC, D'Haens G, Vermeire S, Hanauer SB, Ghosh S, Smith H, Cravets M, Frohna PA, Aranda R, Gujrathi S, Olson A; TOUCHSTONE Study Group. Sandborn Expert Option 审查和测试 WJ, et al. N Engl J Med. 2016 May 5;374(18):1754-62. doi: 10.Expert Option 审查和测试 1056/NEJMoa1513248. N Engl J Med. 2016. PMID: 27144850 Clinical Trial.

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